Stary A, Söltz-Szöts J
Wien Klin Wochenschr. 1983 Dec 9;95(23):823-7.
Genital herpes simplex virus (HSV-)infection is a disease of growing importance in sexually transmitted diseases. It is the most common cause of genital ulcerations throughout the industrialized nations. It is caused by either herpes simplex virus type 1 or 2. Genital herpes displays variable clinical manifestations in a primary or recurrent form. Various seroepidemiologic studies suggest that asymptomatic infection is common. Primary infection causes severe genital lesions and has a relatively high incidence of neurologic and extragenital manifestations. Recurrent episodes are, in contrast, of much milder expression. To exclude the diagnosis of other possible causes of genital ulcers, laboratory confirmation of the diagnosis of genital HSV-infections has to be established, before antiviral therapy is introduced. HSV can be cultivated in cell culture. Rapid diagnostic techniques such as immunofluorescence, cytologic examination and electronmicroscopy are also available. The most promising antiviral drug seems to be acyclovir. It is effective in reducing some of the manifestations of genital HSV infections. However, the most important problems like the prevention of recurrent infections in patients with genital herpes and the transmission of the disease to newborns or to sexual partners, have not yet been solved.
单纯疱疹病毒2型（HSV-2）感染在性传播疾病中愈发重要。在所有工业化国家，它是引起生殖器溃疡最常见的病因。它由1型或2型单纯疱疹病毒引起。生殖器疱疹以原发性或复发性形式表现出多样的临床症状。各种血清流行病学研究表明，无症状感染很常见。原发性感染会导致严重的生殖器病变，并且神经和生殖器外表现的发生率相对较高。相比之下，复发性发作的症状要轻得多。在开始抗病毒治疗之前，必须通过实验室检查确诊生殖器HSV-2感染，以排除其他可能导致生殖器溃疡的病因。HSV-2可在细胞培养中繁殖。快速诊断技术如免疫荧光、细胞学检查和电子显微镜检查也可使用。最有前景的抗病毒药物似乎是阿昔洛韦。它能有效减轻生殖器HSV-2感染的一些症状。然而，诸如预防生殖器疱疹患者的复发感染以及将疾病传播给新生儿或性伴侣等最重要的问题尚未得到解决。
