肽组氨酸异亮氨酸和血管活性肠肽样免疫反应性共存于大鼠垂体门脉血中。
Peptide histidine isoleucine- and vasoactive intestinal polypeptide-like immunoreactivity coexist in rat hypophysial portal blood.
作者信息
Shimatsu A, Kato Y, Inoue T, Christofides N D, Bloom S R, Imura H
出版信息
Neurosci Lett. 1983 Dec 30;43(2-3):259-62. doi: 10.1016/0304-3940(83)90198-2.
Plasma immunoreactive peptide histidine isoleucine (PHI) and vasoactive intestinal polypeptide (VIP) levels were measured by specific radioimmunoassays in urethane-anesthetized rats. Basal levels of plasma PHI-like immunoreactivity (PHI-LI) in the hypophysial portal blood were 414 +/- 180 pmol/l (means +/- S.E.), about 7 times higher than in the peripheral blood. VIP-like immunoreactivity (VIP-LI) was also high in the portal blood (399 +/- 139 pmol/l). The correlation coefficient between PHI-LI and VIP-LI was 0.76. These findings suggest that PHI and VIP are co-released from the median eminence into the hypophysial portal blood in rats.
通过特异性放射免疫测定法，在氨基甲酸乙酯麻醉的大鼠中测量血浆免疫反应性肽组氨酸异亮氨酸（PHI）和血管活性肠肽（VIP）水平。垂体门脉血中血浆PHI样免疫反应性（PHI-LI）的基础水平为414±180 pmol/l（平均值±标准误），约为外周血的7倍。VIP样免疫反应性（VIP-LI）在门脉血中也很高（399±139 pmol/l）。PHI-LI与VIP-LI之间的相关系数为0.76。这些发现表明，PHI和VIP在大鼠中从正中隆起共同释放到垂体门脉血中。
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