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慢性阻塞性肺疾病患者腿部骨骼肌中的肌红蛋白含量

Myoglobin content in leg skeletal muscle in patients with chronic obstructive lung disease.

作者信息

Möller P, Hellström K, Hermansson I L

出版信息

Respiration. 1984;45(1):35-8. doi: 10.1159/000194594.

DOI:10.1159/000194594
PMID:6689796
Abstract

Myoglobin was determined in biopsy specimens from the quadriceps muscle of 3 female and 15 male 48-to 78-year-old patients with chronic obstructive lung disease. The patients were examined after an overnight rest. All but 2 were slightly to moderately hypoxemic. The myoglobin level was in all but 1 instance below the mean previously observed for apparently healthy subjects of similar age. The results are in line with earlier findings of an abnormal pattern of energy-rich phosphagens in the skeletal muscle of patients with chronic obstructive lung disease.

摘要

对3名女性和15名男性、年龄在48至78岁之间的慢性阻塞性肺疾病患者股四头肌活检标本中的肌红蛋白进行了测定。患者在经过一夜休息后接受检查。除2人外,其余患者均有轻度至中度低氧血症。除1例情况外,肌红蛋白水平均低于此前观察到的年龄相仿的明显健康受试者的平均水平。这些结果与早期关于慢性阻塞性肺疾病患者骨骼肌中高能磷酸原异常模式的研究结果一致。

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