Deitch E A, Gelder F, McDonald J C
Arch Surg. 1984 Jan;119(1):83-9. doi: 10.1001/archsurg.1984.01390130065012.
The nonspecific host defense system of 66 patients with thermal injuries was studied prospectively. Our goal was to correlate the magnitude of injury with changes in host defenses and to determine if the responses of patients with and without sepsis were different. Eighteen patients experienced one or more septic episodes. Synchronous serial measurements of circulating fibronectin levels, neutrophil locomotive activity and phagocytosis, and intracellular killing in all patients showed that multiple components of the nonspecific host defense system were impaired after thermal injury. The depression of random migration and chemotaxis and the magnitude of the initial depression in serum fibronectin levels were related to the severity of injury but did not predict sepsis. Only a decrease in neutrophil bactericidal activity or a secondary depression in the serum fibronectin level was associated with the onset of sepsis.
对66例热烧伤患者的非特异性宿主防御系统进行了前瞻性研究。我们的目标是将损伤程度与宿主防御的变化相关联，并确定有脓毒症和无脓毒症患者的反应是否不同。18例患者经历了一次或多次脓毒症发作。对所有患者循环纤维连接蛋白水平、中性粒细胞运动活性和吞噬作用以及细胞内杀伤进行同步连续测量，结果显示热烧伤后非特异性宿主防御系统的多个组成部分受损。随机迁移和趋化性的降低以及血清纤维连接蛋白水平最初的降低程度与损伤严重程度相关，但不能预测脓毒症。只有中性粒细胞杀菌活性降低或血清纤维连接蛋白水平继发性降低与脓毒症的发生有关。
