一种用于前列腺素E和乙酰胆碱的灵敏生物测定法。
A sensitive biological assay for prostaglandin E and acetylcholine.
作者信息
Vapaatalo H, Lindén I B, Parantainen J
出版信息
J Pharm Pharmacol. 1976 Mar;28(3):188-91. doi: 10.1111/j.2042-7158.1976.tb04128.x.
Abstract
Superfused hamster stomach strip has been used in the bioassay of prostaglandin E2 (PGE2) and acetylcholine. The preparation proved very stable and had no spontaneous movements. The sensitivity to PGE2 (and PGE1) was in the range of 10(-9) g ml(-1) and to acetylcholine 10(-12) g ml(-1). After treatment with physostigmine the sensitivity to acetylcholine was 10(-15) g ml(-1). In acetylcholine determination the preparation is more sensitive than any other method.
摘要
灌流的仓鼠胃条已用于前列腺素E2（PGE2）和乙酰胆碱的生物测定。该制剂证明非常稳定，且无自发运动。对PGE2（和PGE1）的敏感性在10（-9）克/毫升范围内，对乙酰胆碱的敏感性为10（-12）克/毫升。用毒扁豆碱处理后，对乙酰胆碱的敏感性为10（-15）克/毫升。在乙酰胆碱测定中，该制剂比任何其他方法都更敏感。
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