多次静脉注射后西咪替丁的动力学

Cimetidine dynamics after repeated intravenous injection.

作者信息

Pancorbo S, Bubrick M P, Chin T W, Miller K W, Onstad G

出版信息

Clin Pharmacol Ther. 1984 Jan;35(1):50-4. doi: 10.1038/clpt.1984.8.

DOI:10.1038/clpt.1984.8

Abstract

Cimetidine dynamics were studied in six multiple-trauma patients receiving 300 to 600 mg every 6 hr for prevention of stress ulceration. Patients received cimetidine intravenously for a mean duration of 7.8 days. There was a positive correlation between cimetidine serum concentration and gastric pH; the correlation between intragastric cimetidine concentration and gastric pH was stronger. The association between therapeutic efficacy (pH greater than 4) and serum concentration over 1 mcg/ml was significant. The association with gastric cimetidine concentration above 2 mcg/ml was significant.

摘要

对6例多发伤患者进行了西咪替丁动力学研究，这些患者每6小时接受300至600毫克西咪替丁以预防应激性溃疡。患者静脉注射西咪替丁的平均持续时间为7.8天。西咪替丁血清浓度与胃pH值之间呈正相关；胃内西咪替丁浓度与胃pH值之间的相关性更强。治疗效果（pH值大于4）与血清浓度超过1微克/毫升之间的关联具有显著性。与胃内西咪替丁浓度高于2微克/毫升之间的关联具有显著性。