Taylor-Courval D, Gloor P
Exp Neurol. 1984 Jan;83(1):167-86. doi: 10.1016/0014-4886(84)90055-4.
Instrumental conditioning procedures demonstrated that in feline generalized penicillin epilepsy (FGPE) the cat's ability to respond to sensory (visual or auditory) stimuli was selectively impaired during penicillin-induced generalized spike and wave (SW) discharge. Responsiveness between SW bursts remained unimpaired. Most often the performance deficit consisted of a total absence of a learned response to stimuli presented during SW bursts or, if such a response occurred, reaction times were on the average significantly longer than to stimuli presented between SW bursts. Stimuli falling in the middle of a SW burst were associated with the highest likelihood of response failure. Spontaneous motor performance which was not contingent on any stimulus was also impaired during SW discharge. Response failure during SW bursts is either attributable to a cognitive defect or to motor impairment associated with temporary amnesia. Impairment of motor performance unassociated with amnesia or a cognitive defect was sometimes present during SW discharge, as evidenced by failure to carry out a motor response or to complete it until the SW burst was over. These deficits are similar to those seen in human absence attacks associated with generalized SW discharge. These observations thus support the validity of FGPE as an acceptable model of human primary generalized epilepsy.
操作性条件反射程序表明，在猫的全身性青霉素癫痫（FGPE）中，在青霉素诱发的全身性棘波和慢波（SW）放电期间，猫对感觉（视觉或听觉）刺激做出反应的能力受到选择性损害。SW爆发之间的反应能力未受损。最常见的表现缺陷包括对SW爆发期间呈现的刺激完全没有习得反应，或者如果出现这样的反应，反应时间平均比SW爆发之间呈现的刺激长得多。落在SW爆发中间的刺激与反应失败的可能性最高相关。在SW放电期间，不依赖于任何刺激的自发运动表现也受到损害。SW爆发期间的反应失败要么归因于认知缺陷，要么归因于与暂时性失忆相关的运动障碍。在SW放电期间，有时会出现与失忆或认知缺陷无关的运动表现受损，表现为未能做出运动反应或直到SW爆发结束才完成反应。这些缺陷与在人类全身性SW放电相关的失神发作中看到的缺陷相似。因此，这些观察结果支持FGPE作为人类原发性全身性癫痫可接受模型的有效性。
