原发性感染血清和IgG1不能阻断宿主对杜氏丝状线虫的保护性免疫。
Primary infection sera and IgG1 do not block host-protective immunity to Nematospiroides dubius.
作者信息
Pritchard D I, Behnke J M, Williams D J
出版信息
Immunology. 1984 Jan;51(1):73-81.
Abstract
IgG1 immunoglobulin purified from sera 3 weeks following primary infection with 400 L3 larvae of Nematospiroides dubius was shown to be protective against challenge infection as assessed by worm recovery and worm length. No evidence was seen of blocking activity either using primary infection sera or IgG1 purified from primary infection sera in a variety of assay systems both in vivo and in vitro. In addition, immune complexes precipitated from primary infection sera by polyethylene glycol failed to inhibit the capacity of immune mesenteric lymph node cells to transfer immunity. It is concluded that an explanation for the prolonged survival of Nematospiroides dubius must be sought in mechanisms other than circulating blocking factors.
摘要
从初次感染400条杜氏丝状线虫L3幼虫3周后的血清中纯化得到的IgG1免疫球蛋白，经蠕虫回收率和蠕虫长度评估，显示对攻击感染具有保护作用。在多种体内和体外检测系统中，无论是使用初次感染血清还是从初次感染血清中纯化的IgG1，均未发现阻断活性的证据。此外，通过聚乙二醇从初次感染血清中沉淀出的免疫复合物未能抑制免疫肠系膜淋巴结细胞转移免疫力的能力。结论是，必须从循环阻断因子以外的机制中寻找杜氏丝状线虫长期存活的解释。
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