Behnke J M, Parish H A
Parasite Immunol. 1981 Autumn;3(3):249-59. doi: 10.1111/j.1365-3024.1981.tb00404.x.
The effect of transferring immune serum (IS) and immune mesenteric lymph node cells (IMLNC) either alone or in combination was studied in NIH mice infected with partially radiation attenuated (5 krad) N. dubius. It was demonstrated that immunity to N. dubius could be transferred with IS and with IMLNC. However, considerably greater protection was transferred to recipient mice when they received both IS + IMLNC. Animals treated in this way had fewer worms than either of the other groups from as early as day 9 onwards, suggesting that a substantial proportion of the worms in mice given IS + IMLNC was retained in the intestinal tissues. The few surviving worms which completed the tissue phase of their development were then rejected by the fourth week of infection. Dose response data showed that as few as 1 x 10(7) IMLNC could cause a significant reduction in worm numbers when given in combination with IS. These experiments indicate that both antibodies (IS) and sensitized lymphoid cells (IMLNC) are required for effective resistance to N. dubius.
在感染了部分辐射减毒（5千拉德）的杜氏小袋纤毛虫的NIH小鼠中，研究了单独或联合转移免疫血清（IS）和免疫肠系膜淋巴结细胞（IMLNC）的效果。结果表明，对杜氏小袋纤毛虫的免疫力可以通过IS和IMLNC转移。然而，当受体小鼠同时接受IS + IMLNC时，转移给它们的保护作用要大得多。从第9天起，以这种方式处理的动物体内的蠕虫数量比其他任何一组都少，这表明接受IS + IMLNC的小鼠体内相当一部分蠕虫滞留在肠道组织中。少数完成组织发育阶段存活下来的蠕虫在感染的第四周被清除。剂量反应数据表明，与IS联合使用时，低至1×10⁷个IMLNC就能显著减少蠕虫数量。这些实验表明，有效的抗杜氏小袋纤毛虫感染需要抗体（IS）和致敏淋巴细胞（IMLNC）两者。
