噬菌体SPO1双突变体HA20的剖析
Dissection of HA20, a double mutant of bacteriophage SPO1.
作者信息
Stewart C R
出版信息
J Virol. 1984 Jan;49(1):300-1. doi: 10.1128/JVI.49.1.300-301.1984.
Abstract
HA20, a mutant of Bacillus subtilis phage SPO1, is deficient in both DNA replication and late transcription. HA20 contains mutations in two different genes, which suggested that the two effects might be caused independently. However, single-mutation derivatives, affected only in gene 27, were deficient for both activities. Thus, a single mutation apparently affects both DNA replication and late transcription.
摘要
HA20是枯草芽孢杆菌噬菌体SPO1的一个突变体，在DNA复制和晚期转录方面均存在缺陷。HA20在两个不同的基因中发生了突变，这表明这两种效应可能是独立产生的。然而，仅在基因27中受影响的单突变衍生物在这两种活性方面均存在缺陷。因此，单个突变显然同时影响DNA复制和晚期转录。
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