Bottomley P A, Hart H R, Edelstein W A, Schenck J F, Smith L S, Leue W M, Mueller O M, Redington R W
Radiology. 1984 Feb;150(2):441-6. doi: 10.1148/radiology.150.2.6691099.
Proton magnetic resonance (MR) images were obtained of the human head in magnetic fields as high as 1.5 Tesla (T) using slotted resonator high radio-frequency (RF) detection coils. The images showed no RF field penetration problems and exhibited an 11 (+/- 1)-fold improvement in signal-to-noise ratio over a .12-T imaging system. The first localized phosphorus 31, carbon 13, and proton MR chemical shift spectra recorded with surface coils from the head and body in the same instrument showed relative concentrations of phosphorus metabolites, triglycerides, and, when correlated with proton images, negligible lipid (-CH2-) signal from brain tissue on the time scale of the imaging experiment. Sugar phosphate and phosphodiester concentrations were significantly elevated in the head compared with muscle. This method should allow the combined assessment of anatomy, metabolism, and biochemistry in both the normal and diseased brain.
使用开槽谐振器高射频（RF）检测线圈，在高达1.5特斯拉（T）的磁场中获取了人类头部的质子磁共振（MR）图像。图像显示没有RF场穿透问题，并且与0.12-T成像系统相比，信噪比提高了11（±1）倍。在同一仪器中，首次用表面线圈从头部和身体记录的局部磷31、碳13和质子MR化学位移谱显示了磷代谢物、甘油三酯的相对浓度，并且当与质子图像相关联时，在成像实验的时间尺度上，来自脑组织的脂质（-CH2-）信号可忽略不计。与肌肉相比，头部的磷酸糖和磷酸二酯浓度显著升高。这种方法应该能够对正常和患病大脑的解剖结构、代谢和生物化学进行综合评估。
