Koren A, Haasz R, Tiatler A, Katzuni E
Am J Dis Child. 1984 Jan;138(1):53-5.
Serum immunoglobulin concentrations (IgG, IgA, and IgM) were measured in 34 children before and after splenectomy. Splenectomy was performed either after trauma or for an underlying hematologic disorder. In the patients with a hematologic disorder, we found a significant decrease in the IgM level after splenectomy. The IgM concentration remained low for a two-year period. Those patients who were "afebrile" during the study period had the lowest IgM levels. No significant changes were observed in the IgM levels in the group that underwent a splenectomy because of trauma. No significant changes were found in IgG or IgA levels in either group. A low IgM level in patients with hematologic disorders may have contributed to a defect in opsonization and to a high incidence of overwhelming infection soon after splenectomy in this group. In the group that underwent a splenectomy because of trauma, the normal IgM level may have protected them and contributed to the lower incidence of infection in this group.
在34名儿童脾切除术前和术后测量了血清免疫球蛋白浓度（IgG、IgA和IgM）。脾切除术在创伤后或因潜在血液系统疾病而进行。在患有血液系统疾病的患者中，我们发现脾切除术后IgM水平显著降低。IgM浓度在两年内一直保持较低水平。在研究期间“无发热”的那些患者IgM水平最低。因创伤接受脾切除术的组中，IgM水平未观察到显著变化。两组的IgG或IgA水平均未发现显著变化。血液系统疾病患者的低IgM水平可能导致了调理作用缺陷，并导致该组脾切除术后暴发性感染的高发生率。在因创伤接受脾切除术的组中，正常的IgM水平可能对他们起到了保护作用，并导致该组感染发生率较低。
