Paganini-Hill A, Krailo M D, Pike M C
Am J Epidemiol. 1984 Jan;119(1):81-5. doi: 10.1093/oxfordjournals.aje.a113728.
Many case-control studies of breast cancer have reported estimates of relative risk of approximately 1.9 for menopause after 54 years of age when compared with menopause before 45 years of age. These estimates may be biased towards unity because of errors in recall of a woman's age at menopause. This paper investigates the magnitude of error associated with self-classification of women into categories of age at menopause by using personal interview and medical record data of 67 control women from a case-control study of breast cancer conducted in two retirement communities near Los Angeles in 1977-1978. These estimates of "misclassification" error are combined with various sets of "true" relative risks to yield "observable" relative risks. It is demonstrated that the relative risks associated with various age at menopause groups are likely to range from 1-3.4 rather than 1-1.9 as has been reported in the literature.
许多乳腺癌病例对照研究报告称，与45岁之前绝经的女性相比，54岁之后绝经的女性相对风险估计约为1.9。由于在回忆女性绝经年龄时存在误差，这些估计可能偏向于1。本文利用1977 - 1978年在洛杉矶附近两个退休社区进行的乳腺癌病例对照研究中67名对照女性的个人访谈和病历数据，调查了女性将自己归入绝经年龄类别时相关误差的大小。这些“错误分类”误差估计与各种“真实”相对风险集相结合，得出“可观察到的”相对风险。结果表明，与不同绝经年龄组相关的相对风险可能在1至3.4之间，而不是文献中所报告的1至1.9。
