Nemeroff C B, Evans D L
Am J Psychiatry. 1984 Feb;141(2):247-9. doi: 10.1176/ajp.141.2.247.
Eighteen psychiatric inpatients who fulfilled DSM-III criteria for major depression and who had a positive dexamethasone suppression test after admission were later retested. Of the 13 patients who exhibited cortisol suppression at discharge, two relapsed within 6 months; five remained nonsuppressors at discharge, and all either required further inpatient care or were symptomatic within 2 weeks to 4 months. Continued cortisol nonsuppression was thus associated with poor clinical response or high risk of relapse.
18名符合《精神疾病诊断与统计手册》第三版（DSM-III）重度抑郁症标准且入院后地塞米松抑制试验呈阳性的精神科住院患者随后接受了重新测试。在出院时表现出皮质醇抑制的13名患者中，有2名在6个月内复发；5名在出院时仍为非抑制者，且所有人在2周内至4个月内都需要进一步住院治疗或出现症状。因此，持续的皮质醇非抑制与临床反应不佳或复发风险高相关。
