Cheung L Y, Sonnenschein L A
Am J Surg. 1984 Jan;147(1):32-7. doi: 10.1016/0002-9610(84)90030-8.
Gastric mucosal blood flow as measured by the hydrogen gas clearance method was compared with total gastric blood flow as determined by venous outflow in an isolated segment of canine stomach. During rest and histamine stimulation, hydrogen gas clearance correlated lineally with total gastric blood flow (p less than 0.001). Correlation analysis revealed a slope of 1.21 and a correlation coefficient of 0.97. The slope of 1.21 indicates that the ratio of mucosal to total gastric blood flow was approximately 82 percent. This fractional distribution of blood flow is in agreement with that previously reported by microsphere technique. In the intact stomach of anesthetized rats and dogs, antral mucosal blood flow was significantly higher than that of the corpus. This finding may, in part, contribute to the observation that acute stress erosion occurs predominantly in the corpus of the stomach. Histamine stimulation selectively increased the mucosal blood flow of the corpus, whereas antral mucosal blood flow remained unchanged. As a result, there was no significant difference in mucosal blood flow between the antrum and the corpus during histamine stimulation.
采用氢气清除法测量的胃黏膜血流量与通过犬胃离体节段静脉流出量测定的胃总血流量进行了比较。在静息状态和组胺刺激期间，氢气清除率与胃总血流量呈线性相关（p<0.001）。相关分析显示斜率为1.21，相关系数为0.97。斜率1.21表明黏膜血流量与胃总血流量的比值约为82%。这种血流的分数分布与先前用微球技术报道的结果一致。在麻醉大鼠和犬的完整胃中，胃窦黏膜血流量显著高于胃体。这一发现可能部分解释了急性应激性糜烂主要发生在胃体部的现象。组胺刺激选择性地增加了胃体的黏膜血流量，而胃窦黏膜血流量保持不变。结果，在组胺刺激期间，胃窦和胃体之间的黏膜血流量没有显著差异。
