Semb B K
Scand J Gastroenterol. 1981;16(6):795-800. doi: 10.3109/00365528109181006.
Gastric microcirculatory changes were studied by means of hydrogen clearance techniques in conscious cats during histamine stimulation. A considerable increase of corpus mucosa flow occurred, whereas a less substantial increase of antrum mucosa flow was observed during stimulation with histamine at 2 micrograms/kg/min, intravenously. Stepwise increase of infused histamine was accompanied by a gradual increase of corpus flow in the mucosa, which during supramaximal stimulation decreased slightly but still remained considerably elevated above control values. A similar decrease of antral mucosa flow occurred earlier during maximal stimulation, suggesting shunting of blood from the antrum to the corpus region. Total gastric flow measurements performed in anesthetized animals similarly showed decreased flow at a rate of histamine infusion which produced supramaximal stimulation in the conscious animals. However, total gastric flow remained elevated also during this stage compared with prestimulation values. A hypothesis of a dual effect of histamine on the gastric circulation is suggested, including regulation of flow through generalized vasodilatation and increased metabolic activity in the parietal cell mass.
在清醒猫身上，采用氢清除技术研究组胺刺激期间胃微循环的变化。静脉注射组胺，剂量为2微克/千克/分钟时，胃体黏膜血流量显著增加，而胃窦黏膜血流量增加幅度较小。组胺输注量逐步增加时，胃体黏膜血流量随之逐渐增加，在超最大刺激时略有下降，但仍显著高于对照值。胃窦黏膜血流量在最大刺激时较早出现类似下降，提示血液从胃窦分流至胃体区域。在麻醉动物身上进行的全胃血流量测量同样显示，在能使清醒动物产生超最大刺激的组胺输注速率下，血流量下降。然而，与刺激前相比，此阶段全胃血流量仍保持升高。由此提出组胺对胃循环具有双重作用的假说，包括通过全身性血管舒张调节血流量以及增加壁细胞群的代谢活性。
