Vree T B, Reekers-Ketting J J, Fragen R J, Arts T H
Anesth Analg. 1984 Jan;63(1):31-4.
Plasma concentrations of midazolam and its metabolites were measured in maternal and fetal blood after intravenous administration of 90 mg of midazolam to seven pregnant ewes in whom sampling catheters had been chronically implanted. Midazolam and its metabolite 1-hydroxymethylmidazolam crossed the placenta of the pregnant ewe. The fetal/maternal plasma concentration ratio of midazolam and the metabolite was 0.15. The distribution and elimination half-lives of midazolam and the metabolite were identical in both maternal and fetal circulations. The major compound found in the urine was the metabolite 1-hydroxymethylmidazolam glucuronide.
对7只长期植入采样导管的怀孕母羊静脉注射90毫克咪达唑仑后，测量母血和胎血中咪达唑仑及其代谢物的血浆浓度。咪达唑仑及其代谢物1-羟基甲基咪达唑仑穿过怀孕母羊的胎盘。咪达唑仑及其代谢物的胎儿/母体血浆浓度比为0.15。咪达唑仑及其代谢物在母体和胎儿循环中的分布半衰期和消除半衰期相同。尿液中发现的主要化合物是代谢物1-羟基甲基咪达唑仑葡糖醛酸苷。
