Rudnev V I, Titov V N
Biull Eksp Biol Med. 1984 Jan;97(1):48-50.
Under the conditions of long-term intravenous perfusion to recipient rats of a solution of rat high density lipoproteins at a concentration exceeding the physiological one and in the absence of stressor components, the animals' liver tissue manifested a significant decrease in free cholesterol. Since the rate of the label incorporation in liver cholesterol increased concurrently, it is suggested that a considerable rise in the content of high density lipoproteins in the blood of rats under the physiological conditions may lead to a fall in liver cholesterol because of which the developing hypocholesterolemia gives rise to the activation of the synthesis of this sterol.
在对受体大鼠进行长期静脉灌注浓度超过生理浓度的大鼠高密度脂蛋白溶液且不存在应激源成分的条件下，动物的肝组织中游离胆固醇显著减少。由于肝脏胆固醇中标记物掺入率同时增加，因此表明在生理条件下大鼠血液中高密度脂蛋白含量的显著升高可能导致肝脏胆固醇下降，由此产生的低胆固醇血症会引发这种固醇合成的激活。
