Chaialo P P
Biull Eksp Biol Med. 1977 Feb;83(2):150-1.
Intraperitoneal injection of C14CH3COONa to normal rats aged 6--8 and 28--32 months revealed a slower dynamics of cholesterol biosynthesis in the liver of old rats at the maximum of the tracer incorporation was lower than in the young ones. Atherogenic diet (0.25 g of cholesterol per 100 g of animal weight for a period of 20 days) was accompanied by an increase in the total cholesterol content and depressio of its biosynthesis in the liver, more pronounced in the young rats. Continued cholesterol administration caused further depression of its biosynthesis, most pronounced (in this case) in the old animals.
给6 - 8个月龄和28 - 32个月龄的正常大鼠腹腔注射C14CH3COONa，结果显示，在示踪剂掺入量达到最大值时，老年大鼠肝脏中胆固醇生物合成的动力学较慢，且低于年轻大鼠。给予致动脉粥样硬化饮食（每100克动物体重含0.25克胆固醇，持续20天）后，总胆固醇含量增加，肝脏中胆固醇生物合成受到抑制，在年轻大鼠中更为明显。持续给予胆固醇会导致其生物合成进一步受到抑制，在老年动物中最为明显（在这种情况下）。
