辣椒素对大鼠脊髓胶状质中的I型突触小球造成选择性损伤。
Capsaicin causes selective damage to type I synaptic glomeruli in rat substantia gelatinosa.
作者信息
Ribeiro-da-Silva A, Coimbra A
出版信息
Brain Res. 1984 Jan 9;290(2):380-3. doi: 10.1016/0006-8993(84)90961-2.
PMID:6692151
Abstract
Most type I synaptic glomeruli were lacking in adult rats given capsaicin neonatally, while topical cord applications of the drug caused dense degeneration of numerous CI- and very few CIIa-terminals. These data give support to the presumable origin of CI-terminals from unmyelinated primary afferents and suggest that CIIa-terminals may belong to small myelinated afferents.
摘要
在新生期给予辣椒素的成年大鼠中，大多数I型突触小球缺乏，而局部应用该药物于脊髓会导致许多CI终末密集退变，CIIa终末极少退变。这些数据支持CI终末可能起源于无髓初级传入纤维的推测，并提示CIIa终末可能属于小的有髓传入纤维。
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