Drago J R
Cancer. 1984 Mar 1;53(5):1093-9. doi: 10.1002/1097-0142(19840301)53:5<1093::aid-cncr2820530513>3.0.co;2-8.
This laboratory unit has been working with the Nb rat prostate adenocarcinoma model for the last several years and has recently used this model system to study efficacy of various chemotherapeutic agents in FANFT-induced bladder carcinomas in this rat strain. The purpose of this project is to identify factors and chemotherapeutic agents that might be useful for treatment of human bladder carcinoma. It is proposed that the use of the Nb rat be utilized to develop a data base to advance understanding of the management of bladder carcinoma induced by FANFT ingestion in Nb rats. Conventional cytotoxic agents and new combination chemotherapy will be utilized intravesically and systemically.
在过去几年中，该实验室一直致力于Nb大鼠前列腺腺癌模型的研究，最近还利用这个模型系统来研究各种化疗药物对该大鼠品系中FANFT诱导的膀胱癌的疗效。本项目的目的是确定可能对治疗人类膀胱癌有用的因素和化疗药物。建议利用Nb大鼠建立一个数据库，以促进对Nb大鼠摄入FANFT诱导的膀胱癌管理的理解。将膀胱内和全身使用传统的细胞毒性药物和新的联合化疗。
