Balkwill F R, Moodie E M
Cancer Res. 1984 Mar;44(3):904-8.
Human lymphoblastoid interferon strongly increased the anti-tumor activity of suboptimal doses of two commonly used anti-cancer drugs, cyclophosphamide and Adriamycin, on a human breast tumor xenograft growing in nude mice. A combination of human lymphoblastoid interferon with either of these agents caused regression and in some cases total disappearance of tumors at doses of drug and interferon that, used singly, were capable only of inhibiting tumor growth. The combined therapy also resulted in a greatly increased survival. Studies with interferon and cyclophosphamide indicated that the antitumor activity was greatest when the two agents were administered simultaneously rather than sequentially.
人淋巴母细胞干扰素显著增强了两种常用抗癌药物（环磷酰胺和阿霉素）亚最佳剂量对裸鼠体内生长的人乳腺肿瘤异种移植瘤的抗肿瘤活性。人淋巴母细胞干扰素与这两种药物中的任何一种联合使用，在单独使用时仅能抑制肿瘤生长的药物和干扰素剂量下，导致肿瘤消退，在某些情况下肿瘤完全消失。联合治疗还使生存期大大延长。干扰素与环磷酰胺的研究表明，当两种药物同时给药而非序贯给药时，抗肿瘤活性最强。
