[The effect of human lymphoblastoid interferon (HLBI) on the growth of 2 human malignant melanoma xenografts in nude mice].

The effects of Human Lymphoblastoid Interferon ( HLBI ) on the growth of 2 human malignant melanoma xenografts in nude mice were investigated. At a dose of 6 X 10(5) IU, the growth of SK-14 was significantly inhibited by intratumoral administration, whereas that of AM-1 was only moderately by inhibited. Tumor cell of SK-14 was found to be degenerated and replaced with melanophages by histological observation, while that of AM-1 showed no significant changes. Dose response of the inhibitory effect of HLBI (6 X 10(5)IU, 1 X 10(5)IU) was investigated against tumor cell of SK-14. At a dose of 6 X 10(5)IU, the growth was strongly inhibited, whereas 1 X 10(5)IU showed only a moderate effect. In conclusion, the sensitivity of malignant melanoma xenograft to the inhibitory effect of HLBI varied with the cell line. It was considered that a relative large dose of HLBI was necessary for an appreciable effect on the malignant melanoma xenograft.