Matsubara Y, Heininger J A, Lin Y Y
Clin Chem. 1984 Feb;30(2):278-80.
Atypical phenylketonuria among infants with hyperphenylalaninemia must be promptly diagnosed and differentiated from classical phenylketonuria, because these patients require different treatment to prevent irreversible neurological damage. Measurement of pteridines in urine by liquid chromatography has been widely used for this purpose. Here we report a rapid, simplified liquid-chromatographic method for simultaneously measuring urinary biopterin, neopterin, and creatinine. Unlike previous methods, this method involves neither tedious cleanup procedures nor special equipment.
高苯丙氨酸血症婴儿中的非典型苯丙酮尿症必须迅速诊断并与经典苯丙酮尿症相鉴别，因为这些患者需要不同的治疗方法以预防不可逆的神经损伤。通过液相色谱法测定尿液中的蝶啶已广泛用于此目的。在此，我们报告一种快速、简化的液相色谱法，用于同时测定尿生物蝶呤、新蝶呤和肌酐。与以往方法不同，该方法既不涉及繁琐的净化程序，也不需要特殊设备。
