Luchins D J, Oliver A P, Wyatt R J
Epilepsia. 1984 Feb;25(1):25-32. doi: 10.1111/j.1528-1157.1984.tb04151.x.
The relative potential of various antidepressants to induce seizures while being used at therapeutic doses was studied by examining their action on spike activity in perfused guinea pig hippocampal slices. Within the range of concentration studied, imipramine, amitriptyline, nortriptyline, maprotiline, and desipramine tended to increase spike activity in a descending order of effect. Doxepin and nomifensine increased spike activity at lower concentrations, but reduced it at higher concentrations. Protriptyline and trimipramine reduced spike activity with increasing concentrations, whereas mianserin and viloxazine had little effect at any concentration. These findings are discussed in light of previous clinical and laboratory reports, and the clinical implications of these findings are presented. Finally, results with the antidepressants are compared with those previously observed with neuroleptics. On the basis of this comparison and a review of clinical reports, the assumption that neuroleptics have greater epileptogenic potential than antidepressants is questioned.
通过研究各种抗抑郁药在治疗剂量下对豚鼠海马灌注切片中尖峰活动的作用，探讨了它们诱发癫痫发作的相对可能性。在所研究的浓度范围内，丙咪嗪、阿米替林、去甲替林、马普替林和地昔帕明倾向于按效应递减顺序增加尖峰活动。多塞平和诺米芬辛在较低浓度下增加尖峰活动，但在较高浓度下降低尖峰活动。普罗替林和曲米帕明随着浓度增加而降低尖峰活动，而米安色林和维洛沙嗪在任何浓度下几乎没有影响。根据先前的临床和实验室报告对这些发现进行了讨论，并阐述了这些发现的临床意义。最后，将抗抑郁药的结果与先前使用抗精神病药观察到的结果进行了比较。基于这种比较和对临床报告的回顾，抗精神病药比抗抑郁药具有更大致癫痫潜力的假设受到质疑。
