Katoh Y, Takayama S
Exp Cell Res. 1984 Jan;150(1):131-40. doi: 10.1016/0014-4827(84)90708-0.
The effects of fibroblast growth factor (FGF) on hamster dermal fibroblasts and chondrogenic cells, both of mesodermal origin, were compared with special reference to growth stimulation and morphological changes in monolayer cultures, and colony formation in semisolid medium. FGF (10 to 200 ng/ml) caused appreciable cell proliferation of dermal fibroblasts but not of chondrogenic cells, while FGF (50-200 ng/ml) caused very marked dose-dependent morphological changes in monolayer cultures and colony formation in semisolid medium of both fibroblasts and chondrogenic cells. It is suggested that FGF is the same type of growth factor as the transforming growth factor(s) because, like the latter, it induces drastic morphological changes of normal mesodermal cells in monolayer cultures and their colony formation in semisolid medium.
比较了成纤维细胞生长因子（FGF）对中胚层来源的仓鼠皮肤成纤维细胞和软骨形成细胞的影响，特别参考了单层培养中的生长刺激和形态变化，以及半固体培养基中的集落形成。FGF（10至200 ng/ml）可引起皮肤成纤维细胞明显的细胞增殖，但对软骨形成细胞无此作用，而FGF（50 - 200 ng/ml）在单层培养中可引起成纤维细胞和软骨形成细胞非常明显的剂量依赖性形态变化，以及在半固体培养基中的集落形成。有人提出FGF与转化生长因子是同一类生长因子，因为与后者一样，它能在单层培养中诱导正常中胚层细胞发生剧烈的形态变化，并在半固体培养基中形成集落。
