Kaufmann M W, Cassem N, Murray G, MacDonald D
J Clin Psychiatry. 1984 Feb;45(2):82-4.
A positive therapeutic response to methylphenidate is described in four depressed patients who developed cardiovascular complications after cardiac surgery that contraindicated the use of tricyclic antidepressants. There was a rapid remission of depressive symptomatology with no adverse side effects. This observation is consistent with the findings of other investigators. Further evaluation of the therapeutic role of psychostimulants in the treatment of medically ill depressed patients is recommended.
四名心脏手术后出现心血管并发症且禁忌使用三环类抗抑郁药的抑郁症患者，对哌甲酯治疗反应呈阳性。抑郁症状迅速缓解，且无不良副作用。这一观察结果与其他研究者的发现一致。建议进一步评估精神兴奋剂在治疗内科疾病所致抑郁症患者中的治疗作用。
