Askinazi C, Weintraub R J, Karamouz N
J Clin Psychiatry. 1986 Sep;47(9):467-9.
The records of 13 medically ill geriatric patients whose depression interfered with their participation in a hospital rehabilitation program were retrospectively reviewed. Treatment with methylphenidate at dosages ranging from 2.5 mg/day to 20 mg/day produced mild to marked improvement in 54% of the patients; the fact that 6 of the 7 responders were female may be indicative of a more responsive subgroup. Methylphenidate treatment of illness-related, nonpsychotic depression in the elderly appears to be an effective, quick-acting, and relatively safe therapeutic option.
对13名患有内科疾病的老年患者的记录进行了回顾性审查，这些患者的抑郁症妨碍了他们参与医院康复项目。使用剂量范围为2.5毫克/天至20毫克/天的哌甲酯进行治疗，使54%的患者有轻度至显著改善；7名有反应的患者中有6名是女性，这一事实可能表明存在一个反应性更高的亚组。哌甲酯治疗老年人与疾病相关的非精神病性抑郁症似乎是一种有效、速效且相对安全的治疗选择。
