Suzuki R, Nitsch C, Fujiwara K, Klatzo I
J Cereb Blood Flow Metab. 1984 Mar;4(1):96-102. doi: 10.1038/jcbfm.1984.12.
Interrelationship between the breakdown of the blood-brain barrier (BBB) to Evans blue and elevations in the regional cerebral blood flow (rCBF) was studied in rabbits subjected to adrenaline- or metaraminol-induced systemic hypertension and also in bicuculline-induced seizures. The rCBF was assessed in small samples from various regions of the brain with the use of [3H]nicotine, and the permeability of the BBB was evaluated with an Evans blue tracer. In acute hypertension, Evans blue extravasations were observed in the occipital cortex and sometimes in the superior colliculus, i.e., the regions which also showed the highest elevations in rCBF. The breakdown of the BBB in acute hypertension was clearly related to the rate of mean arterial blood pressure rise, being much less pronounced in the metaraminol group, which showed a much slower blood pressure elevation rate. In bicuculline-induced seizures, there was no evident correlation between the amplitude of rCBF elevations and Evans blue extravasations. Preservation of BBB integrity was observed in areas showing high elevations in the rCBF.
在接受肾上腺素或间羟胺诱导的全身性高血压的家兔以及荷包牡丹碱诱导的癫痫发作的家兔中，研究了血脑屏障（BBB）对伊文思蓝的通透性破坏与局部脑血流（rCBF）升高之间的相互关系。使用[3H]尼古丁评估来自大脑各个区域的小样本中的rCBF，并使用伊文思蓝示踪剂评估BBB的通透性。在急性高血压中，在枕叶皮质观察到伊文思蓝外渗，有时在上丘也观察到，即这些区域的rCBF也显示出最高的升高。急性高血压中BBB的破坏明显与平均动脉血压升高的速率有关，在间羟胺组中不太明显，该组的血压升高速率要慢得多。在荷包牡丹碱诱导的癫痫发作中，rCBF升高幅度与伊文思蓝外渗之间没有明显的相关性。在rCBF显示出高度升高的区域观察到BBB完整性得以保留。
