Bierman F Z, Yeh M N, Swersky S, Martin E, Wigger J H, Fox H
J Am Coll Cardiol. 1984 Mar;3(3):833-7. doi: 10.1016/s0735-1097(84)80261-2.
Antenatal and postnatal two-dimensional and gated pulsed Doppler echocardiography, beginning at 32 weeks' gestation, were used to evaluate the cardiovascular contribution to nonimmunologic hydrops in a gravida 1, para 0 nineteen year old woman. Antenatal two-dimensional imaging demonstrated a hypoplastic left heart variant of complete common atrioventricular (AV) canal. Antenatal gated pulsed Doppler examination of the fetal thoracoabdominal aorta revealed atypical pandiastolic retrograde flow. Postnatal noninvasive examination at 36 weeks' gestational age was unchanged from the prenatal study. Postmortem examination confirmed the noninvasive anatomic findings and revealed polysplenia. The mechanism of pandiastolic retrograde flow was attributable to "absence of the aortic valve," a previously unreported congenital cardiac anomaly, which resulted in severe antenatal and postnatal aortic regurgitation.
从妊娠32周开始，采用产前和产后二维及门控脉冲多普勒超声心动图，对一名19岁、孕1产0的孕妇进行评估，以确定心血管因素对非免疫性水肿的影响。产前二维成像显示为完全性共同房室通道的左心发育不全变异型。产前对胎儿胸腹主动脉进行门控脉冲多普勒检查，发现非典型的全舒张期逆向血流。孕36周时的产后无创检查结果与产前研究一致。尸检证实了无创解剖学检查结果，并发现多脾。全舒张期逆向血流的机制归因于“主动脉瓣缺如”，这是一种此前未报告过的先天性心脏异常，导致严重的产前和产后主动脉反流。
