Khandelwal J K, Hough L B, Green J P
J Neurochem. 1984 Feb;42(2):519-22. doi: 10.1111/j.1471-4159.1984.tb02708.x.
tele-Methylimidazoleacetic acid (t-MIAA), a major brain histamine metabolite, was measured in nine rat brain regions by a gas chromatography-mass spectrometric method that also measures the precursor amine, tele-methylhistamine (t-MH). The t-MIAA concentration of cerebellum, medulla-pons, midbrain, caudate nucleus, hypothalamus, frontal cortex, hippocampus, and thalamus varied 15-fold, hypothalamus showing the highest level (2.21 nmol/g) and cerebellum the lowest (0.15 nmol/g). The concentrations of t-MIAA and t-MH were significantly correlated in all regions except midbrain, which had relatively more t-MIAA. Probenecid did not alter whole-brain t-MIAA levels. Treatment with pargyline, an inhibitor of monoamine oxidase, lowered the t-MIAA levels in all regions.
通过一种同时测量前体胺——远甲基组胺（t-MH）的气相色谱-质谱法，对九只大鼠脑区中的主要脑组胺代谢物远甲基咪唑乙酸（t-MIAA）进行了测定。小脑、延髓-脑桥、中脑、尾状核、下丘脑、额叶皮质、海马体和丘脑的t-MIAA浓度变化了15倍，其中下丘脑水平最高（2.21 nmol/g），小脑最低（0.15 nmol/g）。除中脑外，所有区域的t-MIAA和t-MH浓度均显著相关，中脑的t-MIAA相对较多。丙磺舒未改变全脑t-MIAA水平。单胺氧化酶抑制剂帕吉林治疗降低了所有区域的t-MIAA水平。
