Prell G D, Green J P
Department of Pharmacology, Mount Sinai School of Medicine, City University of New York, NY 10029.
Agents Actions. 1994 Jun;41 Spec No:C5-8. doi: 10.1007/BF02007743.
Measurements of the concentrations of histamine's metabolites, tele-methylhistamine (t-MH) and tele-methylimidazoleacetic acid (t-MIAA), in brain have been used to evaluate histamine turnover in brains of animals, and the same measurements in CSF have been used to infer histaminergic activity in brains of man. In regions of rat brain, half-lives of histamine are shorter than those of dopamine, 5-hydroxytryptamine and norepinephrine. Studies of human CSF suggest that brain histaminergic activity increases with age and is higher in females than in males.
测量大脑中组胺代谢产物——甲基组胺（t-MH）和甲基咪唑乙酸（t-MIAA）的浓度，已被用于评估动物大脑中的组胺周转率，而对脑脊液进行同样的测量则被用于推断人类大脑中的组胺能活性。在大鼠脑区，组胺的半衰期比多巴胺、5-羟色胺和去甲肾上腺素的半衰期短。对人类脑脊液的研究表明，大脑组胺能活性随年龄增长而增加，且女性高于男性。
