Rieger F, Goudou D, Tran L H
J Neurochem. 1984 Mar;42(3):601-6. doi: 10.1111/j.1471-4159.1984.tb02725.x.
Acetylcholinesterase (AChE) is found both in motor end-plate (MEP)-free and MEP-rich regions of rat or mouse muscle. We studied the developmental aspects of the localization of asymmetric 16S AChE in both regions of the sternocleidomastoid muscle, which has a well-defined zone of motor innervation. In the rat, the proportion of 16S AChE to total AChE increases in the MEP-rich region, and becomes significantly higher than in the MEP-free regions between the first and the second weeks after birth. In the mouse, at birth, the MEP-rich region already has a higher relative content in 16S AChE than the MEP-free regions. Total 16S AChE amounts increase during postnatal development, not only in the MEP-rich region but also in the MEP-free regions. Thus, 16S AChE is not eliminated from MEP-free regions during muscle maturation and growth. Two distinct pools of 16S AChE are distinguished in the muscles, both of which increase during postnatal development: junctional and background 16S AChE.
乙酰胆碱酯酶（AChE）在大鼠或小鼠肌肉中无运动终板（MEP）区域和富含MEP区域均有发现。我们研究了胸锁乳突肌这两个区域中不对称16S AChE定位的发育情况，该肌肉具有明确的运动神经支配区域。在大鼠中，富含MEP区域中16S AChE占总AChE的比例增加，并在出生后第一周和第二周之间显著高于无MEP区域。在小鼠中，出生时富含MEP区域的16S AChE相对含量就已经高于无MEP区域。出生后发育期间，不仅富含MEP区域，无MEP区域的16S AChE总量也增加。因此，在肌肉成熟和生长过程中，16S AChE不会从无MEP区域中消除。肌肉中可区分出两个不同的16S AChE池，在出生后发育过程中二者均增加：接头型和本底型16S AChE。
