Bloch C A, Rothberg A D, Bradlow B A
J Pediatr Gastroenterol Nutr. 1984;3(1):101-3. doi: 10.1097/00005176-198401000-00021.
Previous work from this laboratory has suggested there is a risk of hemorrhagic disease of the newborn (HDNB) in approximately one-third of term neonates, presumably as a result of vitamin K deficiency. Using the same assay for PIVKA (protein induced by vitamin K absence, prothrombin precursor), we studied 46 normal mother-infant pairs at term to investigate the relationship between neonatal and maternal PIVKA status. PIVKA was found in 13 infants (28%) and in seven mothers (15%). Maternal PIVKA status correlated with infant status (p less than 0.03). These data suggest that fetal vitamin K deficiency and risk of HDNB may be a consequence of maternal deficiency of the vitamin.
该实验室之前的研究表明，大约三分之一的足月儿存在新生儿出血性疾病（HDNB）风险，推测这是维生素K缺乏所致。我们采用相同的方法检测无维生素K诱导蛋白（PIVKA，即凝血酶原前体），对46对足月的正常母婴进行研究，以调查新生儿和母亲的PIVKA状态之间的关系。在13名婴儿（28%）和7名母亲（15%）中发现了PIVKA。母亲的PIVKA状态与婴儿的状态相关（p小于0.03）。这些数据表明，胎儿维生素K缺乏和HDNB风险可能是母亲维生素缺乏的结果。
