Argent A C, Rothberg A D, Pienaar N
Pediatr Pharmacol (New York). 1984;4(3):183-7.
Protein in vitamin K absence (PIVKA) is the prothrombin precursor found in plasma when carboxylation to prothrombin is impaired. We report on two cases in which mother-infant PIVKA concentrations were measured at birth after chronic anticonvulsant therapy during pregnancy. Maternal values were 2.4 and 4%, and infant values 20.0 and 18% in cases 1 and 2, respectively. This demonstrates that, despite the normal coagulation profiles previously described, mothers on chronic anticonvulsant therapy may have a subclinical carboxylation defect, while their infants are at risk for hemorrhagic disease. Estimation of maternal PIVKA levels may be of value for predicting risk of hemorrhage in the neonate.
维生素K缺乏诱导蛋白（PIVKA）是在凝血酶原羧化受损时血浆中发现的凝血酶原前体。我们报告了两例在孕期接受慢性抗惊厥治疗后，出生时测量母婴PIVKA浓度的病例。病例1和病例2中，母亲的PIVKA值分别为2.4%和4%，婴儿的PIVKA值分别为20.0%和18%。这表明，尽管先前描述的凝血功能正常，但接受慢性抗惊厥治疗的母亲可能存在亚临床羧化缺陷，而她们的婴儿有患出血性疾病的风险。估计母亲的PIVKA水平可能对预测新生儿出血风险有价值。
