Clark J H, Fitzgerald J F
J Pediatr Gastroenterol Nutr. 1984;3(1):72-6. doi: 10.1097/00005176-198401000-00016.
The effect of exogenous corticosteroid therapy on growth was studied in 12 patients with HBsAg-negative chronic aggressive hepatitis. All patients were less than 13 years of age at diagnosis and were free of cirrhosis. The patients' growth records were retrospectively reviewed for incremental growth changes while they were receiving daily prednisone and alternate-day prednisone, as well as for 1 year after the cessation of therapy. These values were compared with age-matched growth velocities in normal children. Daily steroid therapy was associated with a reduction in growth velocity (p less than 0.01). There was an acceleration in growth velocity during the period of alternate-day therapy, compared with predicted values (p less than 0.03), which persisted during the 1st year after therapy was discontinued (p less than 0.02). Nine of 12 patients crossed growth percentiles during steroid therapy. We have confirmed that daily steroid administration is associated with a reduction in linear growth, while alternate-day therapy has an apparent positive effect on growth, presumably through control of the underlying disease. The mechanism of this supranormal growth rate is unclear.
对外源性皮质类固醇疗法对生长的影响进行了研究，研究对象为12例乙肝表面抗原（HBsAg）阴性的慢性侵袭性肝炎患者。所有患者确诊时年龄均小于13岁，且无肝硬化。回顾性分析了患者在接受每日泼尼松和隔日泼尼松治疗期间以及治疗停止后1年的生长记录，以了解生长的增量变化。将这些数值与年龄匹配的正常儿童的生长速度进行比较。每日类固醇治疗与生长速度降低相关（p<0.01）。与预测值相比，隔日治疗期间生长速度加快（p<0.03），且在治疗停止后的第1年仍持续加快（p<0.02）。12例患者中有9例在类固醇治疗期间跨越了生长百分位数。我们已经证实，每日给予类固醇与线性生长减少相关，而隔日治疗对生长有明显的积极作用，可能是通过控制潜在疾病实现的。这种超常生长速度的机制尚不清楚。
