Chase W F, Winn R E, Mayes G R
Gastroenterology. 1982 Dec;83(6):1292-6.
A young woman with hepatitis B surface antigen negative chronic active hepatitis and hypergammaglobulinemia was treated successfully with oral pulse steroid therapy consisting of prednisone, 90 mg/day, given in repeated 3--5-day courses at 3--4-wk intervals. This approach, which is hypothetically founded on the ability of steroids to cause prolonged inhibition of immunoglobulin G synthesis and proposed mechanisms of hepatocellular damage in chronic active hepatitis, permitted complete clinical, chemical, and histologic remission without morbidity. Oral pulse prednisone therapy deserves further study as a possible adjunct or alternative to existing methods of managing hepatitis B surface antigen negative chronic active hepatitis associated with hypergammaglobulinemia.
一名患有乙肝表面抗原阴性慢性活动性肝炎和高球蛋白血症的年轻女性，采用口服脉冲类固醇疗法成功治愈。该疗法为每日服用90毫克泼尼松，以3至5天为一个疗程，每3至4周重复进行。这种方法理论上基于类固醇能够长期抑制免疫球蛋白G合成的能力以及慢性活动性肝炎中肝细胞损伤的推测机制，实现了完全的临床、化学和组织学缓解且无并发症。口服脉冲泼尼松疗法作为管理与高球蛋白血症相关的乙肝表面抗原阴性慢性活动性肝炎现有方法的可能辅助或替代方法，值得进一步研究。
