2,4-二氨基甲苯在L5178Y小鼠淋巴瘤细胞和AT3-2中国仓鼠卵巢细胞中致突变性的位点特异性。

Locus specificity of mutagenicity of 2,4-diaminotoluene in both L5178Y mouse lymphoma and AT3-2 Chinese hamster ovary cells.

作者信息

Coppinger W J, Brennan S A, Carver J H, Thompson E D

出版信息

Mutat Res. 1984 Feb;135(2):115-23. doi: 10.1016/0165-1218(84)90164-2.

Abstract

2,4-Diaminotoluene, a hepatocarcinogenic aromatic amine, was tested for mutagenic potential at both the autosomal tk locus and the sex-linked hgprt locus of both L5178Y 3.7.2C mouse lymphoma cells and Chinese hamster ovary (CHO) AT3-2 cells. This compound was mutagenic in both cell types at the tk locus but not at the hgprt locus. Mutagenic activity was observed in L5178Y cells only in the absence of exogenous metabolic activation, but was observed in CHO-AT3-2 cells both with and without activation.

摘要

2,4-二氨基甲苯是一种具有肝致癌性的芳香胺，在L5178Y 3.7.2C小鼠淋巴瘤细胞和中国仓鼠卵巢（CHO）AT3-2细胞的常染色体tk位点和性连锁hgprt位点上测试了其致突变潜力。该化合物在两种细胞类型的tk位点均具有致突变性，但在hgprt位点无致突变性。仅在无外源性代谢活化的情况下，L5178Y细胞中观察到致突变活性，但在有或无活化的CHO-AT3-2细胞中均观察到致突变活性。