dl-α-生育酚琥珀酸酯增强了γ射线对培养的神经母细胞瘤细胞的作用。

dl-alpha-Tocopheryl succinate enhances the effect of gamma-irradiation on neuroblastoma cells in culture.

作者信息

Sarria A, Prasad K N

出版信息

Proc Soc Exp Biol Med. 1984 Jan;175(1):88-92. doi: 10.3181/00379727-175-41772.

Abstract

The effect of dl-alpha-tocopheryl (vitamin E) succinate in modifying the radiation response of mouse neuroblastoma (NBP2) and mouse fibroblast (L-cells) cells in culture was studied on the criterion of growth inhibition (due to cell death and inhibition of cell division). Results show that vitamin E succinate markedly enhanced the effect of 60CO-gamma-irradiation on NB cells, but it did not significantly modify the effect of irradiation on mouse fibroblasts. Sodium succinate plus ethanol (0.25% final concentration) did not modify the radiation response of NB cells or fibroblasts. Butylated hydroxyanisole, a lipid soluble antioxidant, also enhanced the effect of irradiation on NB cells, indicating that the effect of vitamin E in modifying the radiation response may be mediated, in part, by antioxidation mechanisms.

摘要

研究了琥珀酸dl-α-生育酚（维生素E）对培养的小鼠神经母细胞瘤（NBP2）和小鼠成纤维细胞（L细胞）辐射反应的影响，以生长抑制（由于细胞死亡和细胞分裂抑制）为标准。结果表明，琥珀酸维生素E显著增强了60Co-γ射线对神经母细胞瘤细胞的照射效果，但对小鼠成纤维细胞的照射效果没有显著影响。琥珀酸钠加乙醇（终浓度0.25%）对神经母细胞瘤细胞或成纤维细胞的辐射反应没有影响。脂溶性抗氧化剂丁基羟基茴香醚也增强了照射对神经母细胞瘤细胞的效果，表明维生素E改变辐射反应的作用可能部分通过抗氧化机制介导。