Lengfelder E, Elstner E F
Hoppe Seylers Z Physiol Chem. 1978 Jun;359(6):751-7. doi: 10.1515/bchm.1978.359.1.751.
The superoxide dismutating activity of the D-penicillamine copper complex was determined and compared with the activities of Cu-Zn and Mn superoxide dismutase in four O2 ground negative earth generating systems. I. Nitrite formation from hydroxylamine. II. Crocin destruction by xanthine/xanthine oxidase. III. Ethylene production by isolated chloroplasts. IV. Nitrite formation from hydroxylamine by chloroplasts in the presence of diquat (1, 1'-dimethylene-2,2'-bipyridylium dibromide). In all four test systems a high dismutative activity of the complex was found, which is not sensitive to KCN as demonstrated with test system III. The results are discussed with regard to the antiinflammatory activity of D-penicillamine.
测定了D-青霉胺铜络合物的超氧化物歧化活性，并在四个O2产生负电荷的体系中与Cu-Zn和Mn超氧化物歧化酶的活性进行了比较。I. 由羟胺生成亚硝酸盐。II. 黄嘌呤/黄嘌呤氧化酶对藏红花素的破坏。III. 分离的叶绿体产生乙烯。IV. 在百草枯（1,1'-二甲基-2,2'-联吡啶二溴化物）存在下，叶绿体由羟胺生成亚硝酸盐。在所有四个测试体系中，均发现该络合物具有较高的歧化活性，如测试体系III所示，该活性对KCN不敏感。结合D-青霉胺的抗炎活性对结果进行了讨论。
