Tyson J E, Mowat G S, McCoshen J A
Am J Obstet Gynecol. 1984 Feb 1;148(3):296-300. doi: 10.1016/s0002-9378(84)80071-x.
As evidence continues to accumulate supporting a specific effect of prolactin on the permeability of reflected fetal membranes to tritiated water, no information on the role of decidual prolactin in this process is available. Simulation of in vivo events was conducted with the use of isolated membrane preparations of human amnion or chorioamnion with adherent decidua. In the presence of ovine prolactin in equal concentrations on both sides of human amnion, membrane permeability (cm X 10(-4) X sec-1) was reduced from 1.52 +/- 0.16 to 1.18 +/- 0.07 (mean +/- SEM) from the fetal to the maternal surface. Permeability in the opposite direction was significantly increased from 1.15 +/- 0.10 to 1.39 +/- 0.08. No osmotic effect of ovine prolactin was noted. With the use of chorioamnion with adherent decidua, permeability was significantly reduced from the maternal to the fetal surfaces only when ovine prolactin bathed the maternal surface. These in vitro results may suggest that the accumulation of decidual prolactin at the choriodecidual interface in vivo supports bulk water flow across fetal membrane from the amniotic to the maternal compartments.
随着越来越多的证据支持催乳素对反射性胎膜对氚化水的通透性具有特定作用，关于蜕膜催乳素在此过程中的作用尚无相关信息。利用分离的带有附着蜕膜的人羊膜或绒毛膜羊膜制备物模拟体内事件。在人羊膜两侧存在等量浓度的绵羊催乳素时，从胎儿表面到母体表面的膜通透性（厘米×10⁻⁴×秒⁻¹）从1.52±0.16降至1.18±0.07（平均值±标准误）。相反方向的通透性从1.15±0.10显著增加至1.39±0.08。未观察到绵羊催乳素的渗透作用。使用带有附着蜕膜的绒毛膜羊膜时，仅当绵羊催乳素作用于母体表面时，从母体表面到胎儿表面的通透性才显著降低。这些体外实验结果可能表明，体内蜕膜催乳素在绒毛膜蜕膜界面的积聚支持了羊水从羊膜腔到母体腔室跨胎膜的大量流动。
