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蜕膜泌乳素对人胎膜和胎盘的免疫调节作用。

Immunomodulatory role of decidual prolactin on the human fetal membranes and placenta.

机构信息

Departamento de Inmunobioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Ciudad de México, Mexico.

Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, Querétaro, Mexico.

出版信息

Front Immunol. 2023 Jun 9;14:1212736. doi: 10.3389/fimmu.2023.1212736. eCollection 2023.

DOI:10.3389/fimmu.2023.1212736
PMID:37359537
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10288977/
Abstract

The close interaction between fetal and maternal cells during pregnancy requires multiple immune-endocrine mechanisms to provide the fetus with a tolerogenic environment and protection against any infectious challenge. The fetal membranes and placenta create a hyperprolactinemic milieu in which prolactin (PRL) synthesized by the maternal decidua is transported through the amnion-chorion and accumulated into the amniotic cavity, where the fetus is bedded in high concentrations during pregnancy. PRL is a pleiotropic immune-neuroendocrine hormone with multiple immunomodulatory functions mainly related to reproduction. However, the biological role of PRL at the maternal-fetal interface has yet to be fully elucidated. In this review, we have summarized the current information on the multiple effects of PRL, focusing on its immunological effects and biological significance for the immune privilege of the maternal-fetal interface.

摘要

妊娠期间胎儿和母体细胞的密切相互作用需要多种免疫内分泌机制为胎儿提供耐受环境并防止任何感染性挑战。胎儿膜和胎盘创造了一个高泌乳素环境，母体蜕膜合成的泌乳素 (PRL) 通过羊膜-绒毛膜转运，并积累到羊膜腔中，胎儿在妊娠期间被高浓度地安置在其中。PRL 是一种具有多种免疫调节功能的多功能免疫神经内分泌激素，主要与生殖有关。然而，PRL 在母体-胎儿界面的生物学作用尚未完全阐明。在这篇综述中，我们总结了 PRL 的多种作用的最新信息，重点介绍了其免疫学作用及其对母体-胎儿界面免疫特权的生物学意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d45/10288977/4d7444f0cb81/fimmu-14-1212736-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d45/10288977/94b680ca9aca/fimmu-14-1212736-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d45/10288977/e445638c316e/fimmu-14-1212736-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d45/10288977/7212df997e13/fimmu-14-1212736-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d45/10288977/843497c591e2/fimmu-14-1212736-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d45/10288977/4d7444f0cb81/fimmu-14-1212736-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d45/10288977/94b680ca9aca/fimmu-14-1212736-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d45/10288977/e445638c316e/fimmu-14-1212736-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d45/10288977/7212df997e13/fimmu-14-1212736-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d45/10288977/843497c591e2/fimmu-14-1212736-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d45/10288977/4d7444f0cb81/fimmu-14-1212736-g005.jpg

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J Reprod Immunol. 2023 Mar;156:103811. doi: 10.1016/j.jri.2023.103811. Epub 2023 Jan 13.
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