Noronha-Dutra A A, Steen E M, Woolf N
Am J Pathol. 1984 Feb;114(2):231-9.
The acute phase of isoproterenol cardiotoxicity in the rat heart was studied by both scanning and transmission electron microscopy. The endocardium and immediate adjacent myocardium of the left ventricle and septum were chosen for examination because this area should be less affected by myocardial underperfusion. The initial damage, which was mainly to the endocardium, was well defined by 30 minutes; this damage consisted of endocardial cell contraction and separation with activated platelets adhering to the exposed subendocardium. Myocardial cell changes were present at 1 hour and always included those cells adjacent to the endocardium; frequently the damage did not extend to involve the deeper tissue layers. Polymorphonuclear leukocytes were present but not in large numbers before three hours. These results suggest that myocardial ischemia due to the action of isoproterenol is not a major factor in isoproterenol cardiotoxicity.
通过扫描电子显微镜和透射电子显微镜研究了异丙肾上腺素对大鼠心脏的急性心脏毒性。选择左心室和室间隔的心内膜及紧邻的心内膜下心肌进行检查，因为该区域受心肌灌注不足的影响较小。30分钟时可清晰观察到主要累及心内膜的初始损伤，表现为心内膜细胞收缩和分离，激活的血小板黏附于暴露的心内膜下。1小时时出现心肌细胞变化，且总是包括紧邻心内膜的那些细胞；损伤通常未扩展至更深的组织层。三小时前存在多形核白细胞，但数量不多。这些结果表明，异丙肾上腺素作用导致的心肌缺血并非异丙肾上腺素心脏毒性的主要因素。
