Steen E M, Noronha-Dutra A A, Woolf N
J Pathol. 1982 Jun;137(2):167-76. doi: 10.1002/path.1711370210.
Isolated beating rat heart myocytes were incubated with the the sympathomimetic amine isoprenaline at concentrations which are known to induce myocardial necrosis in vivo. Incubation with isoprenaline did not induce changes in cell morphology nor impair the ability of the cells to take up and retain fluorescein diacetate. These results suggest that myocardial cells are not the main target in isoprenaline-induced necrosis and that some alternate indirect mechanism must be involved.
将分离的大鼠心脏跳动心肌细胞与拟交感胺异丙肾上腺素一起孵育，其浓度在体内已知会诱发心肌坏死。用异丙肾上腺素孵育不会引起细胞形态的变化，也不会损害细胞摄取和保留荧光素二乙酸酯的能力。这些结果表明，心肌细胞不是异丙肾上腺素诱导坏死的主要靶点，一定涉及一些其他间接机制。
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