Van Vleet J F, Ferrans V J
Am J Pathol. 1984 Mar;114(3):367-79.
Monensin, A Na+-selective carboxylic ionophore, produces left atrial damage in pigs given toxic doses. Eight weanling pigs were given mycelial monensin orally (40 mg/kg body weight) and were killed on days 1, 2, 4, and 16 (two animals at each time interval) for ultrastructural study of the left atrial lesions. On days 1-4, extensive necrosis with contraction bands was present. Rapid macrophagic invasion and phagocytosis of sarcoplasmic debris was seen on days 2 and 4. Missing necrotic myocytes were outlined by persistent "tubes" of external laminas. In some surviving myocytes, sublethal injury was evident on day 1 by mitochondria with condensed conformation and on days 2, 4, and 16 by moderate to marked myofibrillar lysis and sarcoplasmic vacuolation. Monensin cardiotoxicity in pigs constitutes a unique example of selective injury to atrial myocardium.
莫能菌素是一种选择性的钠离子羧酸离子载体，给猪投喂中毒剂量会导致左心房损伤。八只断奶仔猪口服菌丝体莫能菌素（40毫克/千克体重），并在第1、2、4和16天处死（每个时间间隔两只动物），用于对左心房病变进行超微结构研究。在第1至4天，出现了伴有收缩带的广泛坏死。在第2天和第4天，可见巨噬细胞迅速侵入并吞噬肌浆碎片。缺失的坏死心肌细胞由持续存在的外层“管状物”勾勒出轮廓。在一些存活的心肌细胞中，第1天可见线粒体呈浓缩形态，表明存在亚致死性损伤，在第2、4和16天可见中度至明显的肌原纤维溶解和肌浆空泡化。猪的莫能菌素心脏毒性是心房心肌选择性损伤的一个独特例子。
