Davies P G, Fordham J N, Kirwan J R, Barnes C G, Dinning W J
Ann Rheum Dis. 1984 Feb;43(1):70-3. doi: 10.1136/ard.43.1.70.
Skin hypersensitivity to needle puncture (pathergy test) together with a positive HLA B5 antigen has been reported as a diagnostic test for Behçet's syndrome (BS) in Turkish patients. We have studied the pathergy test by 2 methods in 7 healthy volunteers who have the HLA B5(Bw 51 split) antigen and 19 patients with BS. The test was negative in all the normal volunteers and only one of the 19 patients with BS had a positive test by one of the 2 methods. Cluster analysis of our patients and those reported from Turkey showed no difference in their clinical features. The positivity of the pathergy test, and hence its diagnostic usefulness, seem to differ between Britain and Turkey, and we conclude that this difference is not related to the possession of the HLA B5 (Bw 51 split) antigen.
皮肤对针刺的超敏反应(针刺反应试验)以及 HLA B5 抗原阳性,在土耳其患者中已被报道为白塞病(BS)的一种诊断试验。我们采用两种方法对 7 名携带 HLA B5(Bw 51 亚型)抗原的健康志愿者和 19 名白塞病患者进行了针刺反应试验。所有正常志愿者的试验结果均为阴性,19 名白塞病患者中只有 1 名通过两种方法之一检测为阳性。对我们的患者以及来自土耳其报道的患者进行聚类分析,结果显示他们的临床特征并无差异。针刺反应试验的阳性率及其诊断价值在英国和土耳其似乎有所不同,我们得出结论,这种差异与 HLA B5(Bw 51 亚型)抗原的携带情况无关。