Achimastos A, Raison J, Levenson J, Safar M
Arch Intern Med. 1984 Feb;144(2):265-8.
Fat-cell weight, fat-cell number, and hemodynamic indexes were determined in 25 obese men with sustained elevation of BP. Fat-cell weight (and not fat-cell number) was positively correlated with overweight (r = .51) and mean arterial pressure (MAP) (r = .57) in basal conditions. After body weight reduction, BP decreased significantly through a decrease in cardiac index due to a predominant decrease in heart rate. Simultaneously, fat-cell weight decreased significantly. The ratio between the change in BP and the change in body weight, ie, the ability to decrease pressure per unit weight loss, was positively related to the level of initial BP (r = .80) and reached a plateau above 120 mm Hg of the initial MAP. We suggest that, in patients with obesity and hypertension, high BP is associated with hypertrophic obesity, and after body weight reduction, the simultaneous decrease in BP, heart rate, and fat-cell weight could be mediated by neurogenic mechanisms.
对25名血压持续升高的肥胖男性测定了脂肪细胞重量、脂肪细胞数量和血流动力学指标。在基础状态下，脂肪细胞重量（而非脂肪细胞数量）与超重（r = 0.51）和平均动脉压（MAP）（r = 0.57）呈正相关。体重减轻后，由于心率显著下降导致心脏指数降低，血压显著下降。同时，脂肪细胞重量显著降低。血压变化与体重变化的比值，即单位体重减轻时降低血压的能力，与初始血压水平呈正相关（r = 0.80），并在初始MAP高于120 mmHg时达到平台期。我们认为，在肥胖和高血压患者中，高血压与肥厚性肥胖有关，体重减轻后，血压、心率和脂肪细胞重量的同时降低可能由神经源性机制介导。
