Finelli P F, Kessimian N, Bernstein P W
Arch Neurol. 1984 Mar;41(3):330-3. doi: 10.1001/archneur.1984.04050150112027.
Over a period of eight years, a normotensive woman experienced eight strokelike episodes. Computed tomographic (CT) scans obtained during each of the last seven episodes demonstrated intracerebral lobar hemorrhage. Cerebral angiography and contrast-enhanced CT scans demonstrated no underlying abnormality. Our patient had recurrent intracerebral hemorrhage (ICH) with no predisposing factors or dementia. The clinical diagnosis was primary cerebral amyloid angiopathy (CAA). Brain biopsy specimens demonstrated light microscopic and ultrastructural evidence of amyloid in cerebral arterioles. We believe that the combined clinical, CT, and ultrastructural changes in this case are unique. Recurrent ICH visualized by CT scanning has diagnostic value in CAA.
在八年的时间里，一名血压正常的女性经历了八次类似中风的发作。在最后七次发作期间进行的计算机断层扫描（CT）显示脑叶内出血。脑血管造影和增强CT扫描未显示潜在异常。我们的患者反复发生脑出血（ICH），无诱发因素或痴呆。临床诊断为原发性脑淀粉样血管病（CAA）。脑活检标本显示脑小动脉中有淀粉样蛋白的光镜和超微结构证据。我们认为该病例中临床、CT和超微结构的综合变化是独特的。通过CT扫描显示的反复脑出血对CAA具有诊断价值。
