细菌与癌症：成因、巧合还是疗法？综述
Bacteria and cancer: cause, coincidence or cure? A review.
作者信息
Mager D L
机构信息
The Forsyth Institute, 140 The Fenway, Boston, MA, USA.
出版信息
J Transl Med. 2006 Mar 28;4:14. doi: 10.1186/1479-5876-4-14.
Research has found that certain bacteria are associated with human cancers. Their role, however, is still unclear. Convincing evidence links some species to carcinogenesis while others appear promising in the diagnosis, prevention or treatment of cancers. The complex relationship between bacteria and humans is demonstrated by Helicobacter pylori and Salmonella typhi infections. Research has shown that H. pylori can cause gastric cancer or MALT lymphoma in some individuals. In contrast, exposure to H. pylori appears to reduce the risk of esophageal cancer in others. Salmonella typhi infection has been associated with the development of gallbladder cancer; however S. typhi is a promising carrier of therapeutic agents for melanoma, colon and bladder cancers. Thus bacterial species and their roles in particular cancers appear to differ among different individuals. Many species, however, share an important characteristic: highly site-specific colonization. This critical factor may lead to the development of non-invasive diagnostic tests, innovative treatments and cancer vaccines.
研究发现，某些细菌与人类癌症有关。然而，它们的作用仍不明确。有确凿证据表明某些细菌物种与致癌作用有关，而其他一些细菌在癌症的诊断、预防或治疗方面似乎很有前景。幽门螺杆菌和伤寒沙门氏菌感染证明了细菌与人类之间的复杂关系。研究表明，幽门螺杆菌在某些个体中可导致胃癌或黏膜相关淋巴组织淋巴瘤。相比之下，在其他个体中，接触幽门螺杆菌似乎可降低患食管癌的风险。伤寒沙门氏菌感染与胆囊癌的发生有关；然而，伤寒沙门氏菌是黑色素瘤、结肠癌和膀胱癌治疗药物的一种很有前景的载体。因此，细菌物种及其在特定癌症中的作用在不同个体之间似乎有所不同。然而，许多物种具有一个重要特征：高度位点特异性定植。这一关键因素可能会促成非侵入性诊断测试、创新治疗方法和癌症疫苗的发展。
Zotero 插件