Bayliss R, Clarke C, Oakley C, Somerville W, Whitfield A G
Br Heart J. 1983 Dec;50(6):506-12. doi: 10.1136/hrt.50.6.506.
During 1981 and 1982 544 cases of infective endocarditis were investigated retrospectively by means of a questionnaire. Only 13.7% had undergone any dental procedure within three months of the onset of the illness, and in 42.5% there was no known cardiac abnormality before the onset of the disease. Furthermore, the number of cases occurring annually was about the same as or more than it was before the introduction of penicillin. The mouth and nasopharynx were the most likely sources of the commonest organism, Streptococcus viridans, and it is suggested that it is not dental extractions themselves which are of importance but good dental hygiene. In most patients with infective endocarditis the portal of entry of the organism whatever its nature cannot be identified. If this is so antibiotics are being given to only a small proportion of those at risk, and this would explain why the number of cases is much the same as it was before the introduction of penicillin. Furthermore, the large proportion of patients with no known previous cardiac abnormality adds to the difficulty of providing effective prophylaxis. The evidence suggests that antibiotic prophylaxis should still be given before dental procedures, and a schedule is appended. Much more importance should be given, however, to encouraging people to seek better routine dental care. We also believe that doctors and dentists should appreciate that the pattern of the disease has changed considerably in the past 50 years and that the information given here warrants a revised approach to the problem.
1981年至1982年期间,通过问卷调查对544例感染性心内膜炎病例进行了回顾性研究。只有13.7%的患者在发病前三个月内接受过任何牙科治疗,42.5%的患者在疾病发作前没有已知的心脏异常。此外,每年发生的病例数与青霉素引入之前大致相同或更多。口腔和鼻咽是最常见的病原体——草绿色链球菌最可能的来源,有人认为重要的不是拔牙本身,而是良好的口腔卫生。在大多数感染性心内膜炎患者中,无论病原体的性质如何,其进入途径都无法确定。如果是这样,那么只有一小部分有风险的人接受了抗生素治疗,这就解释了为什么病例数与青霉素引入之前大致相同。此外,很大一部分患者之前没有已知的心脏异常,这增加了提供有效预防措施的难度。证据表明,在进行牙科治疗前仍应给予抗生素预防,并附上了一个方案。然而,更应该重视鼓励人们寻求更好的常规牙科护理。我们还认为,医生和牙医应该认识到,在过去50年里,这种疾病的模式发生了很大变化,这里提供的信息值得对这个问题采取一种修订后的方法。