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1
The teeth and infective endocarditis.牙齿与感染性心内膜炎
Br Heart J. 1983 Dec;50(6):506-12. doi: 10.1136/hrt.50.6.506.
2
Infective endocarditis and the dental practitioner: a review of 53 cases involving litigation.
Br Dent J. 1997 Jun 28;182(12):465-8. doi: 10.1038/sj.bdj.4809414.
3
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Cochrane Database Syst Rev. 2004(2):CD003813. doi: 10.1002/14651858.CD003813.pub2.
4
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5
Prevention of infective endocarditis during dental extractions among Polish dentists - a contemporary nationwide survey.波兰牙医在拔牙过程中预防感染性心内膜炎——一项当代全国性调查。
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Br Dent J. 1996 Jul 20;181(2):64-5. doi: 10.1038/sj.bdj.4809160.
7
Teeth and infective endocarditis.
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8
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Predisposing cardiac conditions, interventional procedures, and antibiotic prophylaxis among patients with infective endocarditis.感染性心内膜炎患者的易患心脏状况、介入操作及抗生素预防
Am Heart J. 2016 Sep;179:42-50. doi: 10.1016/j.ahj.2016.03.028. Epub 2016 Jun 17.

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Sci Rep. 2020 Nov 3;10(1):18889. doi: 10.1038/s41598-020-76009-1.
3
Dissemination of periodontal pathogens in the bloodstream after periodontal procedures: a systematic review.牙周治疗后牙周病原体在血液中的播散:一项系统评价
PLoS One. 2014 May 28;9(5):e98271. doi: 10.1371/journal.pone.0098271. eCollection 2014.
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[Prophylaxis of bacterial endocarditis].[细菌性心内膜炎的预防]
Z Kardiol. 2001 Dec;90(Suppl 6):22-6. doi: 10.1007/s003920170004.
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Oral health of patients with severe rheumatic heart disease.重症风湿性心脏病患者的口腔健康状况
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Prevention of infective endocarditis in developing countries.发展中国家感染性心内膜炎的预防
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Bacterial endocarditis: a short overview.细菌性心内膜炎:简要概述。
Can Fam Physician. 1988 Jun;34:1411-5.
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Dentistry and Endocarditis.
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Infective endocarditis caused by Granulicatella elegans originating in the oral cavity.由源自口腔的秀丽颗粒链菌引起的感染性心内膜炎。
J Clin Microbiol. 2005 Mar;43(3):1405-7. doi: 10.1128/JCM.43.3.1405-1407.2005.

本文引用的文献

1
Transitory bacteremia.短暂菌血症
Oral Surg Oral Med Oral Pathol. 1954 Jun;7(6):609-15. doi: 10.1016/0030-4220(54)90071-7.
2
Infective endocarditis, 1970-1979. A study of culture-positive cases in St. Thomas' Hospital.感染性心内膜炎,1970 - 1979年。圣托马斯医院培养阳性病例的研究。
Q J Med. 1980;49(195):315-28.
3
Infective endocarditis.感染性心内膜炎。
Br J Hosp Med. 1980 Sep;24(3):232, 234, 239-43.
4
High-dose oral amoxycillin for preventing endocarditis.高剂量口服阿莫西林预防心内膜炎
Br Med J. 1980 Feb 16;280(6212):446. doi: 10.1136/bmj.280.6212.446.
5
High dose oral erythromycin for preventing endocarditis.大剂量口服红霉素预防心内膜炎
Lancet. 1983 Feb 5;1(8319):299-300. doi: 10.1016/s0140-6736(83)91713-0.
6
10 Years of infective endocarditis at St. Bartholomew's Hospital: analysis of clinical features and treatment in relation to prognosis and mortality.圣巴塞洛缪医院10年感染性心内膜炎病例分析:临床特征及治疗与预后和死亡率的关系
Lancet. 1980 Jan 19;1(8160):133-6. doi: 10.1016/s0140-6736(80)90614-5.
7
Infective endocarditis at the Presbyterian Hospital in New York City from 1938-1967.1938年至1967年纽约长老会医院的感染性心内膜炎。
Am J Med. 1971 Jul;51(1):83-96. doi: 10.1016/0002-9343(71)90326-3.
8
Bacterial endocarditis 1956-1965: analysis of clinical features and treatment in relation to prognosis and mortality.1956 - 1965年细菌性心内膜炎:与预后和死亡率相关的临床特征及治疗分析
Br Heart J. 1969 Sep;31(5):536-42. doi: 10.1136/hrt.31.5.536.
9
Evaluation of transient bacteremia following routine periodontal procedures.常规牙周治疗后短暂菌血症的评估。
J Periodontol. 1973 Dec;44(12):757-62. doi: 10.1902/jop.1973.44.12.757.
10
Infective endocarditis: a review of 125 cases from the University of Washington Hospitals, 1963-72.感染性心内膜炎:对1963年至1972年华盛顿大学医院125例病例的回顾。
Medicine (Baltimore). 1977 Jul;56(4):287-313.

牙齿与感染性心内膜炎

The teeth and infective endocarditis.

作者信息

Bayliss R, Clarke C, Oakley C, Somerville W, Whitfield A G

出版信息

Br Heart J. 1983 Dec;50(6):506-12. doi: 10.1136/hrt.50.6.506.

DOI:10.1136/hrt.50.6.506
PMID:6360190
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC481451/
Abstract

During 1981 and 1982 544 cases of infective endocarditis were investigated retrospectively by means of a questionnaire. Only 13.7% had undergone any dental procedure within three months of the onset of the illness, and in 42.5% there was no known cardiac abnormality before the onset of the disease. Furthermore, the number of cases occurring annually was about the same as or more than it was before the introduction of penicillin. The mouth and nasopharynx were the most likely sources of the commonest organism, Streptococcus viridans, and it is suggested that it is not dental extractions themselves which are of importance but good dental hygiene. In most patients with infective endocarditis the portal of entry of the organism whatever its nature cannot be identified. If this is so antibiotics are being given to only a small proportion of those at risk, and this would explain why the number of cases is much the same as it was before the introduction of penicillin. Furthermore, the large proportion of patients with no known previous cardiac abnormality adds to the difficulty of providing effective prophylaxis. The evidence suggests that antibiotic prophylaxis should still be given before dental procedures, and a schedule is appended. Much more importance should be given, however, to encouraging people to seek better routine dental care. We also believe that doctors and dentists should appreciate that the pattern of the disease has changed considerably in the past 50 years and that the information given here warrants a revised approach to the problem.

摘要

1981年至1982年期间,通过问卷调查对544例感染性心内膜炎病例进行了回顾性研究。只有13.7%的患者在发病前三个月内接受过任何牙科治疗,42.5%的患者在疾病发作前没有已知的心脏异常。此外,每年发生的病例数与青霉素引入之前大致相同或更多。口腔和鼻咽是最常见的病原体——草绿色链球菌最可能的来源,有人认为重要的不是拔牙本身,而是良好的口腔卫生。在大多数感染性心内膜炎患者中,无论病原体的性质如何,其进入途径都无法确定。如果是这样,那么只有一小部分有风险的人接受了抗生素治疗,这就解释了为什么病例数与青霉素引入之前大致相同。此外,很大一部分患者之前没有已知的心脏异常,这增加了提供有效预防措施的难度。证据表明,在进行牙科治疗前仍应给予抗生素预防,并附上了一个方案。然而,更应该重视鼓励人们寻求更好的常规牙科护理。我们还认为,医生和牙医应该认识到,在过去50年里,这种疾病的模式发生了很大变化,这里提供的信息值得对这个问题采取一种修订后的方法。